Abstract
Abstract Vaccine candidates against COVID-19 have diverse compositions, from traditional inac-tivated virus vaccines to various new-generation vaccines. Currently, approximately 175 research teams worldwide are studying various vaccine possibilities as the necessityto vacci-nate the entire population against the SARS-CoV-2 virus is urgent. Although, the development of a safe and effective COVID-19 vaccine is not easy, the manufacturing, distribution, and administration of the vaccine can also face extraordinary challenges. In this review, we enhance some of the current knowledge regarding the clinical trial phases on different COVID-19 vaccine candidates, its potential strengths and disadvantages, and to discuss ethical aspects and their chances of success in large-scale applications.
Highlights
We enhance some of the current knowledge regarding the clinical trial phases on different COVID-19 vaccine candidates, its potential strengths and disadvantages, and to discuss ethical aspects and their chances of success in large-scale applications
An effective vaccine will be crucial in controlling the pandemic, which has already affected about thirty-one million individuals and killed one million people worldwide.[2]
The impactof the humanitarian and economic scale of the COVID-19 pandemic has driven the use of new platforms on vaccine technology to accelerate the research, and the first vaccine candidate entered the clinical trials for humans in mid-March 2020 at an unprecedented speed.[4]
Summary
The genetic sequence of the virus released early on January 11, 2020 triggered intense global research activity to develop a vaccine against the disease.[2] The impactof the humanitarian and economic scale of the COVID-19 pandemic has driven the use of new platforms on vaccine technology to accelerate the research, and the first vaccine candidate entered the clinical trials for humans in mid-March 2020 at an unprecedented speed.[4]
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