Abstract
This review describes briefly the beneficial use of two vaccines developed by us for treatment of cancers. The vaccine against Luteinizing Hormone Releasing Hormone (LHRH) is effective in carcinoma of prostate as well as in breast cancers dependent on androgens and estrogens respectively. LHRH being identical in both males and females, the same vaccine is usable in both Prostate and Breast steroid hormones-dependent-cancers. Monoclonal antibodies are finding therapeutic utility in several cancers, and many have received Drugs Regulatory approval. The monoclonals developed by us against hCG and against epitopes present on androgen-independent castration resistant prostate cancers are briefly recapitulated. Anti-hCG antibodies kill several cancers expressing hCG. An example is given of A549 lung carcinoma. MoAb730 and MoAb7B2G10 kill DU-145 and PC-3 androgen-independent castration resistant prostate cancer cells. Some cancers such as MOLT-4, a T-lymphoblastic leukemia, though expressing hCG are not killed by PiPP, the high affinity anti-hCG antibody. Linking the antibody to curcumin however works like a “Magic Bullet”. All MOLT-4 cells are killed by this conjugate, the antibody homes selectively to cancer cells expressing hCG to deliver curcumin which exercises the killing effect. A recombinant vaccine, hCGβ-LTB (human chorionic gonadotropin subunit β linked to B subunit of heat-labile enterotoxin of E. coli) has been made, which induces high titre bioeffective antibodies not only in BalbC, but also in other genetic strains of mice. The vaccine employs autoclaved Mycobacterium indicus pranii (MiP) as adjuvant. MiP invigorates both humoral and cell mediated immune responses against Human chorionic gonadotropin (hCG). Besides being a potent adjuvant, MiP used alone heals anogenital warts in humans and has the property of preventing and curing SP2/O Myelomas in mice.
Highlights
Carcinoma of Prostate and Breast Cancers are 2 major cancers from which men and women suffer in India and all over the world
These are replaceable by a vaccine against Luteinizing Hormone Releasing Hormone (LHRH)
LHRH is identical in men and women and is a largely conserved decapeptide in all mammals
Summary
Carcinoma of Prostate and Breast Cancers are 2 major cancers from which men and women suffer in India and all over the world. Prostate carcinoma cell proliferation is dependent up to a late stage on testosterone and antiandrogens are employed as drugs to control the cancer. These are replaceable by a vaccine against LHRH. LHRH is a decapeptide hormone which stimulates Follicle stimulating hormone (FSH) and Luteinizing hormone (LH) production by the pituitary. These in turn act on the male/female gonads to generate sperm and egg, and the respective sex hormones: estrogens in the females and testosterone in males. LHRH is identical in men and women and is a largely conserved decapeptide in all mammals. A vaccine against LHRH is usable in both males and females to block eventually the production of testosterone or estrogens, as in dogs and stray animals to block their fertility
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