Vaccine-Derived Polioviruses Not Detected by Global Surveillance Screening Assay.

Deepa K Sharma,Jagadish M Deshpande,Uma P Nalavade,Swapnil Y Varose

doi:10.3201/eid2110.150702

Abstract

Vaccine-Derived Polioviruses Not Detected by Global Surveillance Screening Assay.

Highlights

To mitigate the risk for infection with VDPV type 2, GPEI envisions a simultaneous global switch from trivalent oral poliovirus vaccine (OPV) to bivalent OPV (Sabin[1] and Sabin3)—that is, withdrawal of Sabin2—beginning in April 2016 (5)
Type 3 VDPV was identified in a 1.2-year-old girl with onset of acute flaccid paralysis (AFP) on January 2008
Complete genome sequence of R46064 showed that the major attenuation sites reverted to wild type at nt 472 (U→C) in the 5′ untranslated region (UTR) and nt 2034 in VP3 (U→C)

Summary

Introduction

To mitigate the risk for infection with VDPV type 2, GPEI envisions a simultaneous global switch from trivalent OPV to bivalent OPV (Sabin[1] and Sabin3)—that is, withdrawal of Sabin2—beginning in April 2016 (5). Type 3 VDPV was identified in a 1.2-year-old girl with onset of acute flaccid paralysis (AFP) on January 2008. Sabin[3] was isolated from stool sample 1 (R46064), collected 11 days after onset of paralysis. Stool sample 2, collected on the 13th day after paralysis, was negative for virus.

Results

Conclusion