Abstract
Vaccination has undergone a complete revolution over the past ten decades. With the progress in biotechnology, the present scientific world has witnessed the emergence of a novel vaccine delivery system, called nanovaccines, for eliciting effective humoral, cellular, and mucosal immunity as compared to the conventional vaccination strategies. This novel approach bears innovative methodologies for effective vaccination by arousing beneficial host responses. The different forms of nanovaccine delivery are either microspheres or nanobeads. This chapter discusses in detail the variant forms of nanoparticulate vaccine adjuvants and delivery systems, their interaction with the immune system, and their clinical trial results. Many nanovaccines licensed for human use have proved to be effective carriers for antigens. These immunopotentiators like virosome-based carriers, Immunostimulating Complexes (ISCOMs), polymeric particles, etc. can be formulated as new vaccination methods for curing diseases like HIV, malaria, hepatitis, cancer, etc., thereby cementing the future of the next generation vaccines.
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