Vaccine-Associated Paralytic Poliomyelitis - 8 PLADs, China, October 2012-March 2014.

Ning Wen,Dongyan Wang,Aihu Dong,Yao Liu,Lixin Hao,Shuangli Zhu,Haibo Wang,Fang Fang,Qiru Su,Weizhong Yang,Yu Liu,Keli Li,Wenbo Xu,Yong Zhang,Huaqing Wang,Wendi Wu,Xiaoxiao Zhang,Zhenguo Zhang,Aiqiang Xu,Qiu Tan ,Fuyin Ma ,Yu Wang ,Heng Luo ,Chen Fan ,Lei Zheng

doi:10.46234/ccdcw2020.260

Abstract

Vaccine-Associated Paralytic Poliomyelitis - 8 PLADs, China, October 2012-March 2014.

Highlights

Poliomyelitis is a highly contagious, seasonal viral disease caused by any of three poliovirus (PV) serotypes
vaccineassociated paralytic poliomyelitis (VAPP) is clinically indistinguishable from poliomyelitis caused by wild poliovirus (WPV) and can cause lifelong paralysis
The estimated incidence of VAPP is [2,3,4] cases per million births per year in countries using only Oral poliovirus vaccine (OPV) (3). This is a study that estimated the incidence of VAPP and the association of VAPP with OPV dose number in 8 provincial-level administrative divisions (PLADs) of China

Summary

Introduction

Poliomyelitis is a highly contagious, seasonal viral disease caused by any of three poliovirus (PV) serotypes (types [1, 2], or 3). Oral poliovirus vaccine (OPV) on rare occasions causes vaccineassociated paralytic poliomyelitis (VAPP) in recipients of OPV and close contacts of recently vaccinated individuals. Since the start of the polio eradication program in 1988, an estimated 10 million cases of paralysis have been prevented (2). OPV, on rare occasions, causes vaccine-associated paralytic poliomyelitis (VAPP) in recipients of OPV and close contacts of recently vaccinated individuals. The estimated incidence of VAPP is [2,3,4] cases per million births per year in countries using only OPV (3) This is a study that estimated the incidence of VAPP and the association of VAPP with OPV dose number in 8 provincial-level administrative divisions (PLADs) of China

Methods

Results

Conclusion