Abstract
On page 1627, layered double hydroxide (hexagonal) and hectorite (sheet) nanoparticles are demonstrated to be promising vaccine adjuvants by T. Mahony, Z. P. Xu, and co-workers. The nanoparticles induce sustained, high levels of specific antibodies (IgG and IgA) and a strong cell-mediated response (IFN-γ), in comparison with the commonly-used adjuvant QuilA. Their high adjuvanticity could be attributed to the high antigen loading, facilitation to the antigen cellular uptake and the depot effect.
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