Vaccination and sleep

Abstract

The current worldwide pandemic of a new coronavirus infection has posed new challenges for medicine and the human community. In particular, the issue of widespread mass vaccination and improving its effectiveness has become acute. In this regard, the contribution of sleep to innate and acquired immunity has attracted the attention of researchers. It has been shown that lack of sleep significantly increases the risk of adenovirus infection in healthy young people. For example, people who slept 5-6 hours were 4 times more likely to have a viral infection compared to those who slept 7 hours or more. Several studies have examined the effect of partial sleep deprivation on vaccine effectiveness. Subjects who adhered to a normal, 7-8-hour sleep schedule had a 2.5-fold higher antibody titer for the H1N1 influenza virus than those who slept 4 hours. Studies using polysomnography demonstrated that lack of sleep at night immediately after immunization against hepatitis A virus reduced both humoral and cellular immunity. Consequently, the need to improve sleep quality in the general population also has an epidemiological rationale.