Abstract
It has been shown that the V3 spinal interneurons contribute to locomotion. Here we examined the role of V3 interneurons on sensory transmission. Using confocal microscopy, we found that V3 interneurons receive monosynaptic contacts from sensory afferents and also project monosynaptically back to sensory afferents. Furthermore, intracellular recording of afferents revealed that optogenetic activation of V3 neurons monosynaptically produce a primary afferent depolarization (PAD), with a large NMDA component as well as a classic GABA component. This PAD excites afferents, produces spiking, and in turn drives motoneurons. Furthermore, following V3 neuron activation, subsequent direct activation of sensory afferents caused much attenuated reflexes, likely because the reflex and PAD pathways employ shared V3 neurons. These results suggest that V3 neurons provide an anticipatory activation of afferents (afferent copy). This prepares the spinal cord for actual sensory input and attenuates unwanted sensory evoked motor output during voluntary movements like walking.Support or Funding InformationCanadian Institutes of Health Research; National Institutes of HealthThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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