Abstract
An efficient and facile approach for the synthesis of 5-aminopyrazoles from ketene S,N -acetal and hydrazine hydrate via catalytic reaction under solvent free condition has been described. V 2 O 5 /SiO 2 as a heterogeneous catalyst was prepared and characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM). KEY WORDS : One-pot synthesis, 5-Amino-1 H -pyrazole, Hydrazine hydrate, Vanadium oxide, Silica Bull. Chem. Soc. Ethiop. 2019 , 33(1), 135-142 DOI: https://dx.doi.org/10.4314/bcse.v33i1.13
Highlights
Pyrazoles and their derivatives have attracted considerable interest during the last two decades due to their biological activities
We reported in this paper the synthesis of 5-aminopyrazole derivatives from the ketene acetal with hydrazine hydrate in solvent free condition by using catalysis for simple procedure optimum results than previous methods
The reaction was started by mixing ketene S,N-acetals (10 mmol) and hydrazine hydrate (20 mmol), the V2O5/SiO2 (0.2 g, 20 mol %) was added and the mixture was allowed to stir at 70-80 oC
Summary
Pyrazoles and their derivatives have attracted considerable interest during the last two decades due to their biological activities. Compound A, has been shown to exhibit antifungal activity [1]. Compound B is a potent inhibitors of neutrophil chemotactic responsiveness [2]. Compound C showed antitumor activity by inhibition of cyclindependent kinases (CDK) [3] (Figure 1). Pyrazole compounds used as intermediates in the synthesis of various bioactive compounds such as pyrazolopyrimidines, pyrazolotriazines, pyrazoloquinazolines and Schiff bases [4,5,6,7,8,9]
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