V12-05 THE CYSTOSCOPIC RECONSTRUCTION OF EXTERNAL URETHRAL SPHINCTER TECHNIQUE (CREST) WITH POLYACRYLAMIDE HYDROGEL FOR STRESS URINARY INCONTINENCE

Abstract

You have accessJournal of UrologyCME1 Apr 2023V12-05 THE CYSTOSCOPIC RECONSTRUCTION OF EXTERNAL URETHRAL SPHINCTER TECHNIQUE (CREST) WITH POLYACRYLAMIDE HYDROGEL FOR STRESS URINARY INCONTINENCE Whitney Clearwater, Melissa Laudano, Katherine Panushka, Anna Najor, Ava Leegant, and Nicole Fleischmann Whitney ClearwaterWhitney Clearwater More articles by this author , Melissa LaudanoMelissa Laudano More articles by this author , Katherine PanushkaKatherine Panushka More articles by this author , Anna NajorAnna Najor More articles by this author , Ava LeegantAva Leegant More articles by this author , and Nicole FleischmannNicole Fleischmann More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003347.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Stress urinary incontinence (SUI) is estimated to affect more than 20 million women in the United States. Despite negatively impacting physical, psychological, social, and economic health, less than 2% of women with SUI undergo treatment. Concern for surgical complications and recovery time have been suggested as causes of this disparity. Polyacrylamid hydrogel (PAHG) is a periurethral bulking agent that was FDA approved in 2020. Previous studies report a 60% satisfaction rate and 67% objective cure rate using the standard injection site at the bladder neck. Cystoscopic Reconstruction of the External Sphincter Technique (CREST) is a novel technique for injecting PAHG into the structures of the mid to distal urethra to realign and reconstruct the natural mechanism that prevents SUI in women with all degrees of urethral hypermobility. We seek to describe CREST and present efficacy and complication data. METHODS: This is a retrospective chart review of women>18 years old who underwent CREST with PAHG bulking for management of SUI between March to August 2022 at a single tertiary care center with a single surgeon. Women with either hypermobile or non-hypermobile urethra were included as well as those with stress and mixed urinary incontinence. Women were excluded who had prior treatment for SUI, pelvic organ prolapse greater than stage I or history of radiation therapy to the pelvis. Subjective improvement was defined as self-reporting an improvement in SUI symptoms. Subjective cure was defined as >70% improvement in SUI symptoms and objective cure was defined as negative cough stress test. RESULTS: Forty-eight patients underwent CREST. Ninety-six percent (46/48) reported subjective improvement. Eighty-three percent (40/48) reported >70% improvement in SUI symptoms and 85% (41/48) had negative cough stress test. The mean number of injections was 1.2 (SD 0.4) and median follow-up 38 days (IQR 59.5). Complications included: 10% (5/48) acute urinary retention managed with short term indwelling catheter and 2% (1/48) with denovo urgency incontinence. CONCLUSIONS: CREST is a novel technique for injecting PAHG into the structures of the distal urinary sphincter to realign and reconstruct the natural mechanism that prevents stress urinary incontinence in women with all degrees of urethral hypermobility. Our data suggest this technique is efficacious with minimal complications supporting further evaluation of this technique. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1066 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Whitney Clearwater More articles by this author Melissa Laudano More articles by this author Katherine Panushka More articles by this author Anna Najor More articles by this author Ava Leegant More articles by this author Nicole Fleischmann More articles by this author Expand All Advertisement PDF downloadLoading ...