V10-07 AUTOLOGOUS FAT TRANSFER AS A PROSTATE-RECTAL SPACER FOR PROSTATE BRACHYTHERAPY

Abstract

You have accessJournal of UrologyCME1 Apr 2023V10-07 AUTOLOGOUS FAT TRANSFER AS A PROSTATE-RECTAL SPACER FOR PROSTATE BRACHYTHERAPY Ezequiel Becher, Juan Fernandez Long, Marcelo Bou, Edgardo F Becher, Luis Montes de Oca, and Marcelo Borghi Ezequiel BecherEzequiel Becher More articles by this author , Juan Fernandez LongJuan Fernandez Long More articles by this author , Marcelo BouMarcelo Bou More articles by this author , Edgardo F BecherEdgardo F Becher More articles by this author , Luis Montes de OcaLuis Montes de Oca More articles by this author , and Marcelo BorghiMarcelo Borghi More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003328.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Implanted rectal spacers (IRS) have been developed to increase the distance between the prostate and the rectum, thus optimizing dose escalation in prostate brachytherapy (BT). Cost is a disadvantage and there is a lack of availability worldwide. We have developed an autologous fat transfer (AFT) technique to use as an IRS immediately after the implant of the seeds in low-dose-rate BT. We aim to present the feasibility and durability this technique. METHODS: A total of 120 patients underwent AFT (21 were treated with primary BT, 79 with a combined primary treatment of external beam radiotherapy and BT, 20 with salvage BT). The isodose used for primary BT was 14400 cGy, 11,000 cGy after 4600 cGy of external beam radiotherapy in the combined group, and 14400 cGy for the salvage group. Patients underwent a CT scan at 3, 6 and 12 months to measure the distance between the rectum and the prostate. RESULTS: An average of 18 cc (10-40) of fat was transferred successfully in 100% of cases.The mean distance to the rectum at the level of the base, middle, and apex at 1 and 6 months were 11.2, 9.7, and 7.6 mm; 8.3, 8.1, and 5.9 mm, respectively. No rectal toxicity or major complications were reported. CONCLUSIONS: The use of fat as an IRS seems to be a valid alternative to reduce rectal toxicity after BT, achieving equivalent distances to synthetic IRS. It is feasible, safe, and the loss of distance at 6 months is small. Cost is lower than other alternatives. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e928 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ezequiel Becher More articles by this author Juan Fernandez Long More articles by this author Marcelo Bou More articles by this author Edgardo F Becher More articles by this author Luis Montes de Oca More articles by this author Marcelo Borghi More articles by this author Expand All Advertisement PDF downloadLoading ...