Abstract
1. the adolescent CRMO with fulminant acne and acne-triad (with hidradenitis suppurativa) mostly occurring in male patients, 2. the hyperostotic types of spondarthritis (spondarthritis hyperostotica acne-pustulosa) and 3. other types of acne-associated arthritis and spondarthritis. Three exemplary cases substantiate this not that rarely occurring association, why we want to draw a line from the so called "SAPHO-Syndrome" to the mostly bland and frequently recurring osteomyelitis in form of "acne-CRMO". To the group of possibly causal saprophytes (by may-be immune-reactive processes) Streptococcus mitis and Staphylococcus cohnii have to be added to. The histo-pathological image looks like the combination of plasmacells and sclerosis, that we found in CRMO with pustulosis palmo-plantaris (shown exemplary in a clavicle in case of acne fulminans). With these aspects, the SAPHO-associated symptomatology is "rounded" in a way, but still leaves us with the obligation for a subtle differential diagnosis.
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