V. N. Babichev. Neuroendocrine Regulation of the Reproductive System

Abstract

The problems raised by V. N. Babichev in this monograph on deciphering the central mechanisms of regulation of the pituitary gonadotropic function occupy one of the main places among other issues of neuroendocrinology. To study the sequence of events in neuroendocrine processes that contribute to the preovulatory release of luteinizing hormone is a very complicated but necessary task. In the last decade, neuroendocrinologists are no longer satisfied with a fairly well-studied system of the relationship between gonadaliberin - gonadotropins and sex steroids. The essential role of monoamines of central origin in the regulation of the synthesis and secretion of pituitary gonadotropins, which show their function through luliberins, is shown. Experimenters and clinicians now have rich material that deepens and significantly changes our understanding of the neuroendocrine control of the reproductive system. These literature data in combination with prof. V.N. Babicheva demanded their generalization, which was perfectly done in the peer-reviewed monograph. A comprehensive approach to the study of the entire reproductive function control system, carried out in the laboratory of physiology of the endocrine system of the Russian Academy of Medical Sciences, starting from the period of early ontogenesis, made it possible to specify the role of neurotransmitters such as norepinephrine, dopamine and serotonin in the regulation of the pituitary gonadotropic function, to determine the point of their application in the hypothalamus , the direction of the response from gonadotropins depending on the level of sex hormones in the blood. The starting role of norepinephrine in the mechanism of ovulatory release of gonadotropins has been established, while the main point of its application is the preoptic region. The main point of application of dopamine is the area of ​​the mediobasal hypothalamus, or rather, the arcuate core.