Uvulopalatopharyngoplasty decreases levels of C-reactive protein in patients with obstructive sleep apnea syndrome

Abstract

C-reactive protein is a crucial risk factor for cardiovascular diseases. Previous studies demonstrated that in patients with obstructive sleep apnea syndrome (OSAS), levels of this protein elevate dependently on the degree of upper airway obstruction. However, it has not been determined whether the surgery for OSAS reduces the levels of C-reactive protein by restoring the airway opening. Therefore, we evaluated the effect of uvulopalatopharyngoplasty (UPPP) on levels of serum C-reactive protein in patients with this syndrome. Fifteen adult patients with mild to severe OSAS were enrolled in this study. Levels of serum C-reactive protein and sleep parameters including apnea-hypopnea index a month before and 3 months after UPPP were evaluated using peripheral venous blood and polysomnography, respectively. Uvulopalatopharyngoplasty significantly restored sleep parameters, accompanying with decreased levels of C-reactive protein (from 0.21 +/- 0.17 to 0.10 +/- 0.16 mg/dL, P < .05). In patients with OSAS, UPPP appears to decrease levels of serum C-reactive protein. Surgical therapy may reduce inflammatory response in these patients.