Abstract
Purpose: To report an unusual case of Miller Fisher Syndrome (MFS) in which the patient presented with concurrent right eye uveitis. Case Report: We report a case of a 51-year-old gentleman who presented with typical clinical features of Miller Fisher syndrome including ophthalmoplegia, ataxia, areflexia, ptosis and diplopia following an upper respiratory tract infection. Concurrently, he also had right eye uveitis with raised intraocular pressure. The patient was treated with intravenous immunoglobulin (IVIG), topical steroids and anti-glaucoma eye drops in which he demonstrated good recovery. For diagnostic confirmation, serum antiganglioside antibodies (anti-GQ1b IgG) were later reported to be positive. Conclusion: We described the possible association between MFS and uveitis due to its interrelated pathogenesis. This possible association can lead to early detection and treatment of uveitis.
Highlights
Miller Fisher syndrome (MFS) is a rare immune mediated neuropathy [1]
Case Report: We report a case of a 51-year-old gentleman who presented with typical clinical features of Miller Fisher syndrome including ophthalmoplegia, ataxia, areflexia, ptosis and diplopia following an upper respiratory tract infection
We described the possible association between Miller Fisher Syndrome (MFS) and uveitis due to its interrelated pathogenesis
Summary
In 1956, Charles Miller Fisher reported MFS as a variant of Guillain-Barré Syndrome (GBS), which was first described in 1932 by James Collier [2]. It was based on 3 observed cases characterized by clinical trial of total external ophthalmoplegia, ataxia, and hyporeflexia [2]. The recognition of this disease is important as the presenting neuro-ophthalmological symptoms are often alarming but the course is generally benign [1] [2]. We report an unusual case of MFS in which the patient presented with concurrent right eye uveitis and raised intraocular pressure
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