Uveitis–Glaucoma–Hyphema Syndrome: a Review and Exploration of New Concepts

Abstract

Uveitis–glaucoma–hyphema (UGH) syndrome is a rare but serious complication of cataract extraction and other anterior segment procedures. If left untreated, UGH syndrome can lead to permanent vision loss and visual disability. The purpose of this review is to discuss the etiology, pathogenesis, and presenting signs and symptoms of UGH syndrome. Additionally, we will review the clinical and diagnostic tools used to aid in confirming the diagnosis of UGH syndrome and discuss both the standard and newly developed management strategies for this condition. While the current management of UGH syndrome still involves lens extraction, new surgical techniques designed to preserve the intraocular lens (IOL) have been reported. Additionally, options for IOL reimplantation are discussed. The best treatment for a specific case of UGH syndrome depends on the exact underlying cause of the condition, and as such is variable. We present a variety of recent studies describing novel treatment methods and diagnostic techniques, as well as IOL exchange techniques.