Abstract
Uveal melanoma is the most common primary intraocular malignancy in adults. Despite significant advances in the treatment of primary uveal melanoma, approximately 40–50 % of patients with large tumors develop metastases, with very poor survival after discovery of metastatic disease, despite therapy. To date there is no effective systemic therapy in the adjuvant or advanced uveal melanoma setting. Recent progress in characterizing the molecular nature of primary uveal melanoma offers the possibility of enhancing prognosis and treatment options. This article aims to highlight what is known about potential specific molecular targets that may be amenable to therapeutic intervention.
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