Uveal malign melanomanın karaciğer metastazı-Bir olgu sunumu

Abstract

Melanoma is a neoplastic disorder produced by malignant transformation of normal melanocytes, the cells that produce the pigment melanin. During the first trimester of fetal life, precursor melanocytes arise in the neural crest. As the fetus develops, these cells migrate to areas including the skin, meninges, mucous membranes, upper esophagus, and eyes. In each of these locations, melanocytes have demonstrated a potential for malignant transformation. The eye, central nervous system, gastrointestinal tract, and even the gallbladder have been reported as primary sites of the disease. Melanoma represents 4% to 5% of all skin malignancies. Over 90% are found on the skin; however, 4% of melanomas are discovered as metastases without an identifiable primary site. Although malignant melanoma is only the eighth most common cancer diagnosis in the United States, the large majority (80%) of melanoma patients present in the productive years from age 25 to 65. The mean age for diagnosis of melanoma is 48.