Abstract
Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world’s most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca2+ channels (L-Type VOCC).
Highlights
Ultraviolet (UV)-B filters are chemical substances widely used in personal care products (PCPs), which can act as endocrine disruptor compounds (EDCs) [1,2]
OMC induced vasorelaxation of Human umbilical artery (HUA) rings precontracted with either serotonin (Figure 1A), histamine (Figure 1B) or KCl (Figure 1C)
For His contractions, the three highest OMC concentrations (1–50 μmol/L) caused a significant vasorelaxation compared with the remaining concentrations (p < 0.05, one-way ANOVA with Tukey’s post-hoc test), while in KCl contractions, the highest (50 μmol/L) OMC concentration caused a significantly higher relaxation compared with the other concentrations used (p < 0.05, one-way ANOVA with Tukey’s post-hoc test)
Summary
Ultraviolet (UV)-B filters are chemical substances widely used in personal care products (PCPs), which can act as endocrine disruptor compounds (EDCs) [1,2]. Due to their capacity to interfere with endogenous hormones [3,4], the toxicity of these EDCs is a current concern for human health, mainly in early stages of development such as in embryos, foetuses, infants and children [5,6,7]. HUA is involved in fetoplacental circulation and is an excellent source of vascular smooth muscle cells (SMC) [8,9]. Due to their specific physiological regulation, in vitro studies concerning the intracellular mechanisms modulating HUA contractility are of great importance
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