Abstract
Informational Deoxyribonucleic Acid (iDNA) has gained the attention of many researchers and pioneer companies for the development of novel storage systems for the long-term and high-density storing of information. This research focuses on the physical storage of iDNA strands to address some of the current challenges by evaluating the accuracy of the process of iDNA retrieval from the surface after the dehydration process. For this aim, a UV-Vis spectrophotometric technique was used to measure the concentration of the DNA samples. Although spectroscopy has been widely employed for the evaluation of DNA concentration and contamination in a solution, it has not been used to investigate dry-state DNA, which is one of the preferred storage formats for the long-term retention of information. These results demonstrate that the UV-Vis spectrophotometric technique can be used to accurately measure dry-state DNA before the retrieval and its residues after the DNA retrieval process. This paper further examines the storage/retrieval process by investigating the relationship between the storage time and the amount of retrieved DNA or the DNA residue left on various surfaces. Based on the experimental results demonstrated and discussed in this paper, UV-Vis spectrophotometry can be used for monitoring dry-state DNA with a high accuracy larger than 98%. Moreover, these results reveal that the hydrophilicity and hydrophobicity of the surface do not significantly affect DNA retrieval over a one-month time period.
Highlights
With the rapid growth of the amount of digital data, a huge global demand has emerged for data storage that has motivated cutting-edge research to achieve new technologies for extremely high-capacity memories
This paper investigated the advantages of UV-Vis spectrophotometry for DNA storage in dry mode
The hydrophilicity and hydrophobicity of the surface and the storage time were considered as the factors affecting DNA retrieval
Summary
With the rapid growth of the amount of digital data, a huge global demand has emerged for data storage that has motivated cutting-edge research to achieve new technologies for extremely high-capacity memories. DNA data storage technologies, have recently been proposed for encoding and storing data in new physical media at the molecular or atomic level [4]. DNA molecules have shown the potential of storing the encoded data in both wet and dry forms and their strands represent promising media that could preserve data due to their longevity and immense storage density [5,6,7,8]. Actuators 2021, 10, 246 data in both wet and dry forms and their strands represent promising media that could preserve data due to their longevity and immense storage density [5,6,7,8].
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