UV-vis Spectroelectrochemical In situ Study During the Electrochemical Oxidation of 2-Thiazolamine and 2-Oxazolamine

Abstract

Oxazoles and thiazoles are useful organic compounds in the pharmaceutical industry and agricultural chemistry. For example, the aminothiazole heterocycle system is a useful structural element in medical chemistry and has found wide applications. [1] In previous studies, our group has reported that he electroactivity of 2-aminothiazole and 2-aminooxazole derivate resides on the primary amine group in C-2 position in thiazolic and oxazolic ring respectively and the electron donor ability is mainly governed by 2-aminothiazole and 2-aminooxazole chemistry. [2] Preliminary results, however, have not described or reported the electrochemical behavior of these heterocyclic compounds using in situ coupled techniques. One of the most interesting tools in the characterization of materials is the spectroscopy in the UV-Vis region, because it gives an idea of the compounds present. [3] This interesting technique has been coupled to electrochemicals methods, giving the possibility to in-situ information.In this work, the electrochemical oxidation of 2-Thiazolamine and 2-Oxazolamine is performed utilizing cyclic voltammetry purely electrochemical technique, coupled to UV-vis spectroscopy in situ. The UV–Vis spectra were collected simultaneously while potentiostatic electrolysis was performed. Cyclic voltammetry was carried out using a PalmSens4 potentiostat and Spectroelectrochemical experiments were performed using a quartz curvet of 1 cm path length by placing a commercial screen-printed electrode (IS-1, Italsens), which included a three-electrode configuration printed on the same strip. The preliminary results show the important information provided by UV-Visible spectroscopy coupled with electrochemical techniques.Bibliographic Yichao Wan, Jiabing Long, Han Gao, Zilong Tang, 2021, Eur. J. Med. Chem 210, 15, 112953J A Morales-Morales, A F Villamarin, E Florez-López, J J Rios-Acevedo, 2018 Phys.: Conf. Ser. 1119 012006Noelia González-Diéguez, Alvaro Colina, Jesús López-Palacios, and Aránzazu Heras 2012, Chem. 84, 21, 9146–9153