Abstract
A UV spectrophotometric procedure for determining phenacetin in biological specimens is described. The drug is extracted from biological material by ether and oxidized to a quinone product by cobaltic oxide. The primary metabolite of phenacetin, N-acetyl-p-aminophenol, is assayed by providing a salting-out step in the extraction process. Better than 90% of phenacetin added to urine and serum specimens in vitro at concentrations of 5–50 mcg./ml. was recovered. From homogenized tissue, 83% of added phenacetin was recovered.
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