Abstract
A new simple, rapid, accurate, sensitive and precise spectrophotometric method in ultra violet region has been developed for the determination of levoceterizine dihydrochloride (LCTZ) in bulk drug and tablet dosage form. Levoceterizine dihydrochloride exhibited maximum absorbance at 232 nm with apparent molar absorptivity of 1.5104×104in double distilled water. Beer's law was found to be obeyed in the concentration range of 4-20 µg mL-1. Correlation coefficient was found to be 0.9998. Results of the analysis were validated statistically and by recovery studies. The proposed method is useful for the routine estimation of LCTZ in bulk and tablet dosage form.
Highlights
Levoceterizine dihydrochloride (Figure 1) is chemically 2-[4-[(4-chlorophenyl) phenyl methyl]-1- piperazinyl] ethoxy] acetic acid1 and is a highly effective anti-histamine agent
The present study describes a simple, sensitive, accurate, precise and economical spectrophotometric method for estimation of levoceterizine dihydrochloride (LCTZ) in bulk and tablet formulation
For analysis of LCTZ in tablet dosage form, four commercial brands were procured from the local pharmacy
Summary
Levoceterizine dihydrochloride (Figure 1) is chemically 2-[4-[(4-chlorophenyl) phenyl methyl]-1- piperazinyl] ethoxy] acetic acid1 and is a highly effective anti-histamine agent. The present study describes a simple, sensitive, accurate, precise and economical spectrophotometric method for estimation of LCTZ in bulk and tablet formulation. UV analysis of LCTZ was performed in double distilled water. The method was validated and applied for the determination of LCTZ in tablet dosage form.
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