Abstract
Skin applications of non-thermal atmospheric pressure plasma (NTAPP) have been at-tracting attention from medical and cosmetic aspects. The reactive species generated from plasma sources have been known to play important roles in the skin. For proper applications, it is essential to know how they diffuse into the skin. In this study, the penetration of active species from NTAPP through a skin model was analyzed by UV absorption spectroscopy. The diffusions of hydrogen peroxide, nitrite, and nitrate were quantified through curve fitting. We utilized an agarose gel to mimic epidermis and dermis layers, and we used a lipid film or a pig skin sample to mimic the stratum corneum (SC). The diffusion characteristics of reactive species through this skin model and the limitations of this method were discussed
Highlights
Skin applications of non-thermal atmospheric pressure plasma (NTAPP) have been studied for the last decades, for both medical or cosmetic purposes
The composition of reactive oxygen and nitrogen species (RONS) from NTAPP can be tailored by using different feeding gases, which may result in differential biological responses [14,15]
Since 1 mm agarose gel film is very thin and flexible, it is deformed with long treatment
Summary
Skin applications of non-thermal atmospheric pressure plasma (NTAPP) have been studied for the last decades, for both medical or cosmetic purposes. Positive effects of plasma have been reported for blood coagulation [1,2], wound healing [3,4], tissue regeneration [5], cancer treatment [6,7], drug delivery [8,9] and cosmetic purposes such as acne treatment and anti-aging [10,11]. These positive effects are attributed to the various reactive oxygen and nitrogen species (RONS) occurring in the plasma. The composition of RONS from NTAPP can be tailored by using different feeding gases, which may result in differential biological responses [14,15]
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