Abstract
Results Computational analyses of the novel UTR sequences, focusing on RNA-binding protein (RNAbp) interaction motifs revealed strongly over-represented RNAbps with known roles in nervous system pathologies. We consider the implications of 3’UTR transcript extension and protein interaction in the context of axonal plasticity and the consequences of mis-regulation of this process during neurological disease.
Highlights
The 3’-untranslated region (3’UTR) of mRNA transcripts contributes to cell-type specific or developmental-stage specific regulation of gene functions by modifying cellular localization, stability and/or translational efficiency of transcripts.Published: 29 September 2014 doi:10.1186/1471-2105-15-S10-P11 Cite this article as: Harrison et al.: UTR extension and alternate polyadenylation in neuroplasticity: an emerging paradigm? BMC Bioinformatics 2014 15(Suppl 10):P11
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Summary
The 3’-untranslated region (3’UTR) of mRNA transcripts contributes to cell-type specific or developmental-stage specific regulation of gene functions by modifying cellular localization, stability and/or translational efficiency of transcripts.Published: 29 September 2014 doi:10.1186/1471-2105-15-S10-P11 Cite this article as: Harrison et al.: UTR extension and alternate polyadenylation in neuroplasticity: an emerging paradigm? BMC Bioinformatics 2014 15(Suppl 10):P11. UTR extension and alternate polyadenylation in neuroplasticity: an emerging paradigm? Benjamin J Harrison1†, Robert M Flight2†, Abdallah M Eteleeb3†, Eric C Rouchka3*, Jeffrey C Petruska1,4,5*
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