Abstract
We report the synthesis of the novel scaffolds pyrazino[1,2- b]isoquinoline and pyrrolo[1,2- a]pyrazine displaying the somatostatin pharmacophores. Both classes of compounds contain a pyrazine heterocycle, which can be prepared in a straightforward manner utilizing an intramolecular Fukuyama–Mitsunobu reaction. As both the families derive from amino acids, they can be accessed in high optical purity.
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