Utilizing Angiogenic Agents to Enhance and Expedite the Neovascularization Process in Skin Flaps

Abstract

At the recent spring meeting of the American Academy of Facial Plastic and Reconstructive Surgery in Palm Beach, Fla, Dr David B. Hom, Ypsilanti, Mich, and Drs Shan R. Baker, Linda M. Graham, and Ken D. McClutchey, Ann Arbor, Mich, presented a study utilizing angiogenic agents to enhance the neovascularization of skin flaps. Their purpose was to determine if and what optimum concentration of angiogenic agents can speed up neovascularization. Endothelial cell–growth supplement applied topically, with and without gel foam, and endothelial cell–growth factor were the agents studied. White rabbits' ears were used and island flaps were raised, based on the radial artery distribution. On day 3 postoperatively, the central vascular pedicle was ligated. On day 10 postoperatively, the carotid arteries were cannulated, and the dye was continuously infused. Statistically, significant results were obtained in the endothelial cell–growth supplement plus gel foam–treated flaps vs the control or nontreated flaps.