Abstract
Diabetes mellitus is the chronic disorder emerging as major world health problem which increases the rate of morbidity and mortality. The aim of the present study was to ascertain patterns of prescription of oral hypoglycemic agents to type 2 diabetic patients attending a university hospital, and to assess patient compliance. A prospective, observational and non comparative study was conducted in 200 established diabetes mellitus type 2 patients attending outpatient department at Majeedia Hospital, New Delhi, India. Prescriptions from registered patients were included in the study. Once the consultation by the physician was over, the prescriptions were reviewed and the patients were interviewed. The information was collected in an inhouse designed documentation proforma. In a pool of 200 type 2 diabetics, more than half were female (n=106, 53%). The mean age of the patients were found to be 50.4 ± 11.7 years and mean body mass index, 25.8 ± 4.4 kg/m2. A total of 432 oral hypoglycemic agents were prescribed to the patients. Highly significant number of patients were prescribed combination therapy, (n=143, 71.5%) as compared to monotherapy (n=57, 28.5%), p-value
Highlights
Diabetes mellitus (DM) is one of the oldest diseases known to man, which was the first reported in Egyptian literature about 3000 years ago [1]
People living with type 2 DM are more vulnerable to various forms of both short and long-term complications, which often lead to their premature death
Sir Edward Albert Sharpey-Schafer in 1910 found that diabetes resulted from lack of insulin
Summary
Diabetes mellitus (DM) is one of the oldest diseases known to man, which was the first reported in Egyptian literature about 3000 years ago [1]. The name diabetes was first given by the Greek Physician Aretaeus (30 90CE). Avicenna, is the famous Arabian physician who first described the complications and progression of the disease [2]. In 1889, Joseph von Mering and Oskar Minkowski discovered the role of pancreas in diabetes. Sir Edward Albert Sharpey-Schafer in 1910 found that diabetes resulted from lack of insulin. Best and Collip purified the hormone insulin from pancreas of cows at the University of Toronto. This led to the availability of an effective treatment for diabetes in 1922. Trials to prepare an orally administrated antidiabetic agent ended successfully after first marketing of tolbutamide and carbutamide in 1955
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