Utilization of the dialysate to characterize dialysis adequacy by using microwave urea biosensor based on complementary split-ring resonator (CSRR)

Abstract

The aim of this study is going to develop a monitoring approach for measuring blood urea concentration. This method uses microwave technology and complementary split-ring resonator (CSRR) to assess dialysis adequacy. The robust electric field near CSRR sides produces a high-sensitivity surface to a change in the nearby urea level. The proposed biosensor detection range spans from 1 to 100 mg/dL by modifying resonance frequency and peak attenuation. The biosensor was developed to operate at the main resonance frequency of 2.4 GHz, but all harmonics within the frequency range of 1–10 GHz were analyzed. A container incorporates the dialysate as the material being tested on the top of the sensor. Accurate measurement of blood urea variations using spent dialysate compared to the blood-based method has benefits due primarily to the lack of repetitive blood sampling. The innovative biosensor offers a non-invasive and convenient method to accurately evaluate the quantitative urea concentration in spent dialysate without the necessity of disposable chemicals. The biosensor has been designed to possess noteworthy attributes such as detecting minuscule concentration variations, low-cost fabrication, compact size, high sensitivity, and its ability to provide real-time results. By merging these features, the sensor demonstrates remarkable potential for non-invasively monitoring blood urea levels while seamlessly integrating with other dialysis devices. The initiative purpose of this study is going to offer renal patients methods for assessing dialysis adequacy with minimal impact on human health.