Abstract
Rapid advancement in medicine and biotechnology has driven the field of drug discovery. Novel approaches of drug delivery such as formulating the polymeric nanoparticles is revolutionizing the future of medicines. Newly potent and target specific drugs led to enhance therapeutic utility. These challenges, coupled with the complexity and variety, are fueling the advancement of novel drug delivery systems that overcome bioavailability and delivery obstacles. In present scenario, nanoparticles have been acting as carriers for delivering a wide range of potential drugs. Due to their versatility and wide range of properties and they represent a promising drug delivery system of controlled and targeted release. The utilization of polymeric nanoparticles is a plan that aims to minimize adverse effect and will optimize therapeutic effects. Nanoparticle-based therapy facilitates safe and efficacious therapy for cancer patients. Advancement in Nanomedicine technologies provides clear evidence that polymeric nanotherapies have a significant impact in oncology. Improvement in therapeutic utility of polymeric nano-particulate system is highlighted in this paper. This review deals with the polymeric nanoparticulate systems, fate of nanoparticles, its types, targetting mechanism, application and recent patents.
Highlights
Nanoparticle is a term may be defined as a particle having either one or more dimensions of the order of 1000 nm size or less
Due to lack of target specificity and advocating high toxic adverse effect, chemotherapy is less opted for cancer treatment
This review focuses on polymer-based targeted nanocarriers considering therapeutic aspects in the field of oncology
Summary
Nanoparticle is a term may be defined as a particle having either one or more dimensions of the order of 1000 nm size or less. Magnetic: Biocompatible Magnetic nanoparticles like maghemite Fe2O3 and Fe3O4 (magnetite) have been dynamically investigated for targeted cancer treatment e.g. Magnetic hyperthermia) guided drug delivery, gene therapy, Magnetic Resonance Imaging (MRI), sorting and manipulation of stem cells [16]. The Nanoparticles drug delivery system has enormous advantages over other delivery systems like due to their small size, capability to penetrate through smaller capillaries and is taken up by cells, which facilitates efficient drug accumulation at the target sites Another point, biodegradable materials has been used for preparation of nanoparticles. The merits of ceramic nanoparticles over other carrier system are small size, porosity, and resistibility in pH has wide application in industry of modern materials science including drug delivery system [7]. Materials like nanopores of pore-sizes in nanometer have a significant role in industry [26]
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