Abstract
AbstractIn the present study attempt is made to substitute soft paraffin, a common commercial ointment base, with cheap fatty material like palm stearin. Palm stearin has been corandomised with coconut oil and tested as potential ointment base. The products show release of salicylic acid, a sparingly water soluble drug, much better than soft paraffin tested in vitro and in vivo and also sodium salicylate a water soluble drug, in the presence of surfactants as additives. They are also suitable ointment bases with respect to slip melting point, plasticity and consistency.
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