Abstract
Tablet formulations and data to illustrate rate of drug dissolution and tablet volume decay during in vitro disintegration tests are presented. It was found that tablets prepared by compression of hydrophilic gums, excipients, and drug in specified ratios result in prolonged release of drug. Assay of simulated gastric and intestinal fluids from in vitro tests show the drug to be released at essentially a uniform rate after an initial hydration phase. The mechanism of prolonged release is proposed as a combination of drug diffusion from, and attrition of, a dynamically changing gel barrier at the tablet periphery.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
