Utilization of hepaplastintest for diagnosis and prognosis of liver diseases

Abstract

In four groups of liver diseases, Hepaplastin test and other coagulation tests were studied and compared with various liver function tests.The value of Hepaplastin test in liver cirrhosis revealed 49.1%±16.8 S. D., in acute hepatitis 69.7%±17.5 and in chronic hepatitis 71.5%±16.8.In 5 cases of 7 cholestasis, in which the value of Hepaplastin test remained normal, obstructive Lipoprotein (Lp-X) were positive. But in all cases of 6 cholestasis, in which the value of Hepaplastin test were reduced, Lp-X were negative.The value of Hepaplastin test revealed good correlation with Choline esterase, α-Lipoprotein and Lecithin-cholesterol acyl transferase activity which reflect the reduction of synthesis in liver cells, and also revealed good correlation with ICG-R15.It is already known that the osmotic fragility of RBC decreases in liver diseases. We found that the value of Hepaplastin test correlated with the end osmotic pressure of hemolysis of RBC measured by Coil planet centrifuge system.We judged the prognosis of hepatitis by considering the combination of Hepaplestintest and α-Lipoprotein value. The patients that the value of Hepaplastin test and α-Lipoprotein remained normal in spite of the remarkable elevation of S-GOT, made rapid recovery. In the value of Hepaplastintest and α-Lipoprotein recovered after normalization of S-GOT, the elevation of S-GOT recurred after a few monthes.Hepaplastintest, test for extrinsic clotting system which measures factors II, VII and X is said to reflect the liver function. In our study, Hepaplastin test seems to be usefull for the judgement of prognosis of liver diseases except cholestasis.