Utilization of glucose, fructose and invert sugar; comparison in diseases of the liver and pancreas.

Abstract

Although numerous reports dealing with the comparative utilization of infused glucose, fructose, and invert sugar have appeared in the recent surgical and biochemical literature, the results of these studies are still equivocal. Certain investigations have indicated that fructose and invert sugar are superior to glucose for parenteral feeding purposes; others have suggested the reverse. In previous studies Weichselbaum, 1 Elman and Lund, using infusion rates of 0.6 to 2 gm. per kilogram per hour, reported that after fructose the urine contained little sugar as compared with glucose. The diuretic effect was less pronounced with fructose. Lawton and Curreri and Gale found that a 10% solution of invert sugar can be given more rapidly and is more completely utilized than glucose. 2 They also noted a lessened diuretic effect with invert sugar. In this study 1 liter of solution was infused at a rate of 1.5 gm. per kilogram body weight