Abstract
Abstract An efficient one-pot synthesis of β-lactams by the reaction of imines with acetic acid derivatives in the presence of DMF and benzoyl chloride adduct, a cheap reagent, has been described. Optimization of solvents, temperature, and molar ratio of reagent was also performed. Several types of β-lactams including monocyclic, spirocyclic, N-alkyl, 3-butadienyl, and 3-electron-withdrawing group have been synthesized by this method in good to excellent yields. All steps of the reaction proceed at room temperature.
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