Abstract
Markers of cell proliferation are widely used as diagnostic and prognostic tools. Coincident estimation of these markers increases the precise evaluation of the proliferative status of different tissues and can also be helpful in determining progression, aggressiveness and prognosis of the lesions. The current study investigated the expression of PCNA and MCM3 cell proliferation markers in 40 formalin fixed paraffin embedded tissue blocks of odontogenic keratocyst (OKC) and unicystic ameloblastoma (UA) cases using immunohistochemistry method. Markers` expression based on the intensity, percentage of positively stained cells and localization of reaction through the cyst lining epithelium was separately analyzed for each marker using Chi square test, the results of which were significant for the two markers (P < 0.05). Both markers revealed statistically significant differences between OKC and UA cases regarding markers expression intensity, positivity score and localization of reaction through the epithelium. Mural UA histologic variant was significantly different than luminal and intraluminal variants. The correlation coefficient between the two markers was found to be 0.86.
Highlights
Odontogenic cysts and tumors are heterogeneous group of osteo-destructive lesions that had varied clinical and biological behavior [1]
To understand the differences between Odontogenic keratocyst (OKC) and unicystic ameloblastoma (UA) that could be useful for diagnosis and therapeutic purposes, the current study evaluated PCNA and MCM3 immunohistochemical expression in OKC and the three histologic variants of UA
It consisted of odontogenic epithelium lining and fibrous connective tissue wall, with tumor extending into the cystic luminal space (Fig. 1)
Summary
Odontogenic cysts and tumors are heterogeneous group of osteo-destructive lesions that had varied clinical and biological behavior [1]. OKCs are the most common developmental odontogenic cysts that originate from cell rests of dental lamina [2]. OKC has aggressive biological behavior and high recurrence rate thats why the term keratocystic odontogenic tumor (KOT) was suggested by WHO classification in 2005 [3, 4]. WHO reclassified it again as OKC in 2017 because of insufficient evidence to support the neoplastic origin [5]. Previous studies have suggested that increased epithelial activity in OKC is responsible for the aggressiveness of this lesion in comparison with other odontogenic cysts [7, 8]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
