Utilization of cargo from extra cellular vesicles as a biomarker for endometrial receptivity for enhancement of implantation success during attempted IVF/ICSI- a short communication

Abstract

Earlier we reviewed how the Extra cellular vesicles (ECV) s might work as biomarkers in case of both female as well as male reproductive diseases that is inclusive of ART, besides the methods of obtaining the same. Here in extension of the same Li evaluated the ECVs obtained from the uterine fluid aspirated with observing small noncoding ribonucleic acids(sncRNA) that were identified from these ECV’s. Despite, their conclusions of this being the first study that exhaustively profiled sncRNA in endometrial ECV s from uterine fluid as well as isolated biomarkers of endometrial receptivity in addition to implantation the critiques have not accepted it with flaws of the study of utilization of only fresh embryo transfers (ET) for evaluation with current utilization of frozen ETs besides not attempting preimplantation genetic testing for aneuploidy(PGT-A), for distinguish ng euploid from aneuploid embryo s further in the fresh ETs as wella. Further it is accepted that once 3 euploid embryos transferred in case of 3 consecutive IVF <5% had chances of recurrent implantation failure((RIF) as well as further studies are required for establishment of these sncRNA from ECVs as biomarkers