Utilization and turnover rate of fructose during continuous intravenous infusion in pre-term and term newborns in dependence on age.

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Fructose turnover and utilization in dependence on age were examined in 55 pre-term and term newborns appropriate for gestational age during continuous intravenous infusion of fructose (0.25–1.0 g . kg<sup>––</sup><sup>1</sup> · h<sup>––1</sup>). (1) The linear turnover range of fructose is exceeded during the first 3 days of life independently of gestational age with infusions of 1.0 g · kg<sup>––1</sup> · h<sup>––1</sup>. This, however, is not the case in pre-term and term infants 10–12 days old. For the postnatal development of the fructose metabolism, the age of life is important, but not the gestational age. (2) During the first 3 days of life in pre-term and term infants, less than 10% of the fructose infused are eliminated. Thus, the fructose utilization is high even in the neonatal period, amounting to more than 90%. (3) The influence of fructose on the blood glucose concentration is not uniform and depends on fructose intake rate, gestational age, and age of life. Hypoglycemias were not observed.