Abstract
Olanzapine is a derived of tienobenzodiazepina that integrate in a group of second generation of antipsychotics drugs. It was aproved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) in the year 1996 for the treatment of schizophrenia, and in the same year the EMA authorizes their use in bipolar disorder. Sooner it was approved for the treatment of depressive Bipolar Disord episodes in combination with fluoxetine (FDA, year 2003), treatment in long term and prevention relapses of bipolar disorderI (FDA, year 2004) and resistant depression in combination with fluoxetine (FDA, year 2009).The authors carried out a critical and thorough review of existing scientific evidence about the efficacy and safety of olanzapine in schizophrenia and bipolarI disorder.
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