Utility Values in Colorectal Cancer Patients Treated with Chemotherapy

Majid Atfannezhad,Mehran Sharifi,Farzan Madadizadeh,Hosein Ameri

doi:10.1080/07357907.2021.1992632

Abstract

Calculating utility values in colorectal cancer (CRC) patients under chemotherapy treatment is important for studies of economic evaluations. The EQ-5D-5L and composite time trade-off (cTTO) were used to calculate utility values in 105 patients with CRC in Iran. The mean EQ-5D-5L index and cTTO values were 0.45 ± 0.03 and 0.51 ± 0.02, respectively. The anxiety and pain were the most common problems reported by the patients. The BetaMix showed that lower mean utility values were significantly associated with female, aging, a low level of income, a greater number of comorbidities and advanced stage of cancer.

Highlights

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in both sexes[1]
Univariate analyses showed that the difference between the mean EQ-5D5L index values were significant for age, education status, income level, stage of cancer, and comorbidity number; showed that the difference between the mean composite TTO (cTTO) values were significant for age, income level, employment status, stage of cancer, and comorbidity number
The beta mixture (BetaMix) showed that lower mean utility values were significantly associated with female, aging, a low level of income, a greater number of comorbidities and advanced stage of cancer

Summary

Introduction

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in both sexes[1]. According to the latest report by International Agency for Research on Cancer in Iran, the most common cancer types diagnosed in males were the stomach, prostate, colorectal and in females were breast, colorectal, and stomach. In both sexes combined, CRC is the second or third most common cancer found in the country[2]. EuroQoL five- dimension (EQ-5D), which is the most common indirect method in measuring utility, is commonly used This instrument is usually employed in two version: The EQ-5D 3levels (EQ-5D-3L)(8) and the EQ-5D 5level(EQ-5D-5L)(9). In light of this lack of data, this study aimed to measure the utility values in CRC under chemotherapy treatment and identify factors associated with them

Objectives

Results

Conclusion