Abstract
Utility of Trend of Nephrocheck® (IGFBP7 × TIMP-2) Biomarker for Early Identification of Acute Kidney Injury in Critically Ill Patients with Sepsis or Respiratory Failure
Highlights
Many studies have shown the association between acute kidney injury (AKI) and morbidity and mortality in the Intensive Care Unit (ICU)
The trend of the Nephrocheck® values was more significant than the initial value for the development of AKI
The Nephrocheck® test may be used as an early indicator of development of AKI
Summary
Many studies have shown the association between acute kidney injury (AKI) and morbidity and mortality in the Intensive Care Unit (ICU). Various definitions have been developed to classify these patients according to severity of kidney injury for purposes of identification, management, and prognostication of the need for renal replacement therapy (RRT), re-hospitalization, and death. These scales include RIFLE (Risk, Injury, Failure, Loss, and End-stage Kidney Disease), AKIN (Acute Kidney Injury Network), and KDIGO (Kidney Disease: Improving Global Outcomes) [2]. These definitions use serum creatinine and urine output in a scoring system which reflect an insult or injury that occurred. Earlier identification of acute kidney injury may lead to earlier interventions, which potentially could prevent the progression of the renal injury and improve patient outcomes
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