Abstract
Patients withthis condition demonstrate clonal hematopoietic expansion,cytopenias, myelodysplasia, ineffective hematopoiesis andan increased propensity to develop acute myeloid leukemia.Not surprisingly, prognosis is related to severity of cytopenias,presence of cytogenetic abnormalities and clonal evolutiondemonstrated by blast counts, and other ‘traditional’ progno-stic elements. There is heterogeneity even among patientsdiagnosed with lower-risk disease, since a subset of thesepatients have more aggressive disease. Recent efforts havedemonstrated that several molecular parameters linked tothe pathophysiology of MDS may affect overall survival.
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