Abstract

Genetic predisposition to venous thrombosis and elevation in total homocysteine (HC) levels from mutations in the methylenetetrahydrofolate reductase (MTHFR) gene have been described as having roles in the pathogenesis of recurrent pregnancy loss (RPL). Although a serum HC level has been recommended as a screening test for MTHFR polymorphism in women with RPL, the value of this assay remains unclear. The purpose of this study was to determine the frequency of elevated HC levels in women with RPL, and to assess the association between HC levels and common MTHFR polymorphisms.

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