Abstract
Aspirin-exacerbated respiratory disease (AERD) is a disease of the upper and lower airways characterized by asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and acute upper and/or lower airway symptoms triggered by cyclooxygenase-1 inhibitors. Individuals with AERD have more severe upper and lower airway disease, poorer quality of life (QoL), and increased medication utilization than their aspirin-tolerant asthma and CRSwNP counterparts.1 The high rate of nasal polyp recurrence despite adequate surgical excision in patients with AERD is major driver of health care utilization and impaired QoL.
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