Abstract
We appreciate the thoughtful comments by Boyko (1). The premise of our study (2) was to understand whether homeostasis model assessment (HOMA) of β-cell function (HOMA-β) had utility in predicting diabetes development above and beyond glucose concentration in a large sample of individuals. We concluded that it did not. Even in narrowly defined glucose categories (normal fasting glucose [NFG], <5.6 mmol/l; impaired fasting glucose [IFG]-100, 5.6–6.0 mmol/l; and IFG-110, 6.1–6.9 mmol/l), baseline glucose concentrations …
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