Abstract
The aim was to determine whether promoter methylation of BRCA1, MGMT, MLH1, RASSF1A, and p16 genes could predict response to platinum-based chemotherapy. Thirty-five subjects with epithelial ovarian cancer (EOC) treated by platinum-based chemotherapy were recruited. Methylation-specific polymerase chain reaction was carried out and the methylation index (MI) was also derived. Response to platinum-based chemotherapy was documented clinically, radiologically, and by serial CA125 levels. Methylated BRCA1 (p =. 037) and a higher MI (p =. 045) were associated with primary chemosensitivity. A better outcome was predicted by a higher MI (p =. 032). In EOC, BRCA1 gene promoter methylation is useful in the prediction of response to chemotherapy.
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