Abstract
Glioma (astrocytoma) is one of the most common primary intra-axial CNS neoplasm and glioblastoma (GBM) is the most aggressive form of astrocytoma (grade IV). According to Central Brain Tumor Registry of the United States (CBTRUS), GBM is the most common primary malignant primary CNS neoplasm with median survival of only 15 months.
Highlights
IntroductionGlioma (astrocytoma) is one of the most common primary intra-axial CNS neoplasm and glioblastoma (GBM) is the most aggressive form of astrocytoma (grade IV)
Glioma is one of the most common primary intra-axial CNS neoplasm and glioblastoma (GBM) is the most aggressive form of astrocytoma
With emergence of new treatment options on the horizon, imaging precision is important to treatment planning. In this mini-review, we aim to demonstrate utility of efficacy of preneurosurgical planning for GBM using functional MRI and 3D tractography
Summary
Glioma (astrocytoma) is one of the most common primary intra-axial CNS neoplasm and glioblastoma (GBM) is the most aggressive form of astrocytoma (grade IV). With emergence of new treatment options on the horizon, imaging precision is important to treatment planning. In this mini-review, we aim to demonstrate utility of efficacy of preneurosurgical planning for GBM using functional MRI (fMRI) and 3D tractography. Task-based Functional MRI (fMRI) detects activation of neurons in the eloquent brain regions using Blood oxygen level dependent (BOLD) sequence. Neuronal depolarization leads to transient change in blood flow in region of activation which results in differential oxygenated-to-deoxygenated hemoglobin concentration. This differential results in positive signal on MRI BOLD sequence. Advanced post-processing techniques can provide 3-dimensional (3D) evaluation of white matter tracts, commonly referred to as 3D tractography
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