Utility of Focused Re-screening of Liquid-based Papanicolaou Tests Diagnosed as Negative for Intraepithelial Lesion/Malignancy with Positive High-Risk HPV in an Academic Tertiary Care Center: Comparison with Follow-up Cytology/Biopsy

Abstract

Conclusions: Evaluation of HR-HPV/ASC-US of three consecutive years reveals a slightly skewed rate during the transition year of implementing the new screening guidelines for early detection and prevention of cervical cancer. Though there is a slightly increase in ASC and SIL rates over the three years, the ASC/SIL ratio remains around 75th percentile, reflecting a stable screening performance of the institutional laboratory during this transition. Continued monitoring of institutional HR-HPV/ASC-US and ASC/SIL, including those of individual cytopathologist and cytotechnologist is required for quality control and assurance of the laboratory and individual performance.