Utility of Certain π‐Acceptors for the Spectrophotometric Determination of Tranexamic Acid in Commercial Dosage Forms

Abstract

In this study, two simple, fast, accurate, and sensitive spectrophotometric methods have been developed for the determination of tranexamic acid in commercial dosage forms. These methods (A and B) are based on the reaction of tranexamic acid as n‐electron donor with 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ) and 7,7,8,8‐tetracyanoquinodimethane (TCNQ) as π‐acceptors to give highly colored complex species that absorb maximally at 470 and 750 nm, respectively. Beer's law was obeyed in the concentration limit of 0.5–10 µg/mL for tranexamic acid. The limit of detection (LOD) and limit of quantification (LOQ) were calculated and found to be 0.18 µg/mL and 0.60 µg/mL for method A and 0.12 µg/mL and 0.39 µg/mL for method B, respectively. A Job's plot of the absorbance versus the molar ratio of tranexamic acid to each of the acceptors under consideration indicated 1∶1. The proposed methods were found to be rapid, accurate, precise, and sensitive for the determination of tranexamic acid in commercial dosage forms without interferences from common additives encountered.