Utility of cardiovascular magnetic resonance imaging in patients with malignant ventricular arrhythmias

Abstract

Methods Consecutive patients with resuscitated SCD or sustained were enrolled. Imaging was performed using either a 1.5 T or 3 T MRI scanner. Standard cine imaging was performed in serial short axis planes followed by T2-wighted turbo spin-echo imaging using a triple inversion recovery sequence (STIR) in the same planes. DE imaging was performed in matched slice orientations following the administration of 0.125 to 0.2 mmol/kg gadolinium intravenously. T1-weighted imaging (axial slices) was additionally performed in patients with LBBB morphology. All images were blindly interpreted using visual scoring. T2 and DE images were also evaluated by semiautomated quantitative techniques. Results 67 patients were enrolled (24 with SCD, 43 with) with a mean age of 51 ± 15 years. Myocardial disease was known to be present in 33 patients (49%); prior myocardial infarction (MI) in 18, dilated cardiomyopathy (DCM) in 4 and hypertrophic cardiomyopathy (HCM) in 1. The mean ejection fraction (EF) was 53 ± 18% with 32 patients (48%) having an EF >55%. T2 weighted imaging was abnormal in 10 patients (15%) with findings consistent with acute myocarditis in 7 and ischemic injury in 3. DE imaging was abnormal in 35 patients (52%) with findings consistent with MI in 20, hypertrophic cardiomyopathy (HCM) in 9, myocarditis in 6 and sarcoidosis in 2. Two patients had a combined MI-HCM DE pattern. Of 15 patients enrolled with LBBB morphology the T1 weighted imaging was abnormal in 2. Overall, myocardial tissue disease was demonstrated by CMR in 41 patients (62%). A new myocardial disease or change in diagnosis was provided by CMR in 14 patients (21%).